We know that Margaret was born in Dublin from the 1851 census of England and we have an idea of her surname from the birth certificates of her twins, Margaret and Thomas, on which it appears to be 'Nead', a very unusual but not unknown surname in Ireland. However on the birth certificate of her daughter Mary Ann, Margaret's surname appears to be 'Made'. Made could also have been a pronunciation of the relatively common Irish name Mead (back then it wasn't unusual for names to be spelled as they were locally pronounced, such as Clary for Clery, Ragan for Regan, etc.). Variations of Nead and Mead appear to be Neade and Meade respectively, with Meade being a more common spelling than Mead.
It's a long shot but it's possible Margaret's father's first name was Robert and her mother's Lucy because baptismal records have been found on the Irish Genealogy website www.irishgenealogy.ie for three children of a Robert and Lucy Mead/Made in (the Catholic) St. Andrew's parish in Dublin. While none of the children is named Margaret, Margaret's middle name is Lucy, one of her children was named Robert and the name of one of the baptismal sponsors is Maria Anna Butler (Margaret would marry a George Butler). Although this is no evidence whatsoever of a connection between Margaret and the family of Robert and Lucy Mead, just in case there is a link, here are the details from the Irish Genealogy records:
Louisa Mead (sic), baptised 1809, sponsors Andrew OHalen (sic) and Maria Anna Butler
Robert Meade (sic), baptised 1810, sponsors Francis McDermott and Anna McDermott
Robert Made (sic), baptised 1811, sponsors Francis McDermott and Anna McDermott (either there is an error or the first Robert had died)
Margaret and her husband moved from Dublin to London around 1830. According to both the 1841 and 1851 censuses of England, Margaret, George and their family were living at 1 Francis Court in the parish of St. Paul, Covent Garden in Westminster. By the time of the 1861 census, they were living at 57 Greek St. (where their musical instrument business was located) in the parish of St. Anne in Westminster and at the time of Margaret's death in 1868 they were living at 29 Haymarket (again, the address of their business). Margaret died from 'dropsy', an old term for the 'swelling of soft tissues due to the accumulation of excess water, often due to congestive heart failure').
In case Margaret's surname was the unusual name of Nead (or Neade), a search of Irish civil registration records on the FamilySearch website shows small concentrations of Nead families around Delvin, Co. Westmeath (which has by far the highest number of records); Strokestown, Co. Roscommon; Dublin; Roscommon town; Mullingar, Co. Westmeath; Carrick-on-Shannon, Co. Leitrim; and Ballyvaughan, Co. Clare.
Griffith's Valuation (1847-1864): Michael Nead, occupier of land in the parish of Cloonygormican, Co. Mayo; Julia Nead, occupier in the parish of Killulagh in Co. Westmeath
Dublin City Census (1851): Pk. (Patrick?) Neade, 1 Hammond Lane in the parish of Michan's in Dublin; Jno. (John?), 17 Hammond Lane in St. Michan's
1841 Census of England: Mary Nead, Liverpool, born c.1791 Ireland; Michael, Croydon, born c.1821 Ireland
1851 Census of England: Catherine Nead, born c.1813 Co. Cork, married to English-born Thomas Nead; James Nead, born c.1824 Mayo and his wife, Elizabeth, born c.1811 Cork, living St. Pancras, London
1861 Census of England: No Irish-born Neads recorded
1871 Census of England: No Irish-born Neads recorded
1881 Census of England: Ann Nead, born c.1830 Ireland, married to English-born John Nead, living Wigan; Thomas Nead, born c.1824 Ireland; his wife, Eliza, born c.1819 Ireland; their son Michael, born St. Pancras, all living St. George, Bloomsbury; James Nead, born c.1857 Ireland, lodger in Cumberland; Thomas Nead, born c.1861 Ireland, lodger in Cumberland
1891 Census of England: Julia Nead, born c.1818 Co. Cork, living Shoreditch
1901 Census of England: Joseph Nead, born c.1864 Ireland and his wife, Mary, born c.1856, living Sale
Monica Evans in the UK has kindly provided me with some information on the family of her father, Patrick Neade, who was probably born in Drogheda, Co. Louth. Patrick's father, also named Patrick, whose date and place of birth are unknown, married Clare Bannon in the 1900s and they had five children:
Patrick (1909-1977)
John (1910-1983)
Mary (c.1914-2002)
Clare (c.1920-1982)
Annie (1922-1977)
It's believed the eldest three children were born in Drogheda and the youngest two on a farm in Williamstown, Delvin, Mullingar, Co. Westmeath where Patrick and his family settled after serving with the British Army during World War I. All five children emigrated to England. During World War II Patrick and John found engineering work at a factory near Gloucester; Mary and Clare worked for the American Red Cross, both marrying American soldiers and moving to the United States where they raised families. Patrick married in 1952 and Annie about 1955. Both had families. John never married and returned to Williamstown following the death of his father in 1955. Clare (his mother) died in 1969 and John in 1983. All three are buried in the same plot in the cemetery at Williamstown church.